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DeCS
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Descriptor English:
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Antibody Diversity
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Descriptor Spanish:
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diversidad de anticuerpos
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Descriptor Portuguese:
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Diversidade de Anticorpos
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Synonyms English:
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Antibody Diversities
Diversities, Antibody
Diversity, Antibody
Germ Line Theories
Germ Line Theory
Theories, Germ Line
Theory, Germ Line
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Tree Number:
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G05.365.036
G12.500.199
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Definition English:
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The phenomenon of immense variability characteristic of ANTIBODIES. It enables the IMMUNE SYSTEM to react specifically against the essentially unlimited kinds of ANTIGENS it encounters. Antibody diversity is accounted for by three main theories: (1) the Germ Line Theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; (2) the Somatic Mutation Theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and (3) the Gene Rearrangement Theory, which holds that antibody diversity is generated by the rearrangement of IMMUNOGLOBULIN VARIABLE REGION gene segments during the differentiation of the ANTIBODY-PRODUCING CELLS. |
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History Note English:
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80
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Allowable Qualifiers English:
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Record Number:
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926
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Unique Identifier:
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D000916
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Occurrence in VHL:
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Similar:
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DeCS
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